Glial brain tumor targeting of magnetite nanoparticles in rats

After intravenous injection into rats, nanodispersed iron preparations accumulated in internal organs but not in the brain. Hyperosmotic blood-brain barrier disruption followed by injection of magnetite-dextran nanoparticles into the carotid artery resulted in penetration of particles into the brain tumor and peritumoral tissue of the rats bearing glial brain tumor and T-2-weighted magnetic resonance imaging (MRI) images showed pronounced signal loss in the tumor region. (C) 2001 Elsevier Science B.V. All rights reserved.