期刊
BIOCHEMISTRY
卷 49, 期 29, 页码 5989-5997出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi100393r
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资金
- Oklahoma Center for the Advancement of Science and Technology [HR09-160]
- National Science Foundation [0902027]
- American Cancer Society [090039]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0844913] Funding Source: National Science Foundation
- Direct For Education and Human Resources
- Division Of Human Resource Development [0902027] Funding Source: National Science Foundation
The Bacillus subtilis phage 029 packaging motor requires prohead RNA for genome encapsidation. The nuclear magnetic resonance structure of the prohead RNA E-loop hairpin, r(5'AUUGAGUU), is presented and compared to predictions from MC-SYM. The prohead RNA E-loop hairpins contain sequences similar to rRNA hairpins. Comparison of predicted and experimentally determined prohead and ribosomal hairpin structures reveals that sequence similarity is a stronger determinant of hairpin structural similarity than grouping similar types of RNA. All the hairpins contain a U-turn motif but differ in the first noncanonical pair and backbone orientation. These structures provide benchmarks for further improvements in RNA structure predictions from sequence.
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