期刊
FEMS MICROBIOLOGY REVIEWS
卷 25, 期 2, 页码 245-268出版社
OXFORD UNIV PRESS
DOI: 10.1016/S0168-6445(00)00066-8
关键词
virulence assay; Candida albicans; gene disruption; pathogenic fungus; dimorphism
类别
In recent years, the incidence of fungal infections has been rising all over the world. Although the amount of research in the field of pathogenic fungi has also increased, there is still a need for the identification of reliable determinants of virulence. In this review, we focus on identified Candida albicans genes whose deletant strains have been tested in experimental virulence assays. We discuss the putative relationship of these genes to virulence and also outline the use of new different systems to examine the precise effect in virulence of different genes. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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