期刊
MOLECULAR CELL
卷 7, 期 4, 页码 753-765出版社
CELL PRESS
DOI: 10.1016/S1097-2765(01)00220-9
关键词
-
资金
- Howard Hughes Medical Institute Funding Source: Medline
The Drosophila bonus (bon) gene encodes a homolog of the vertebrate TIF1 transcriptional cofactors. bon is required for male viability, molting, and numerous events in metamorphosis including leg elongation, bristle development, and pigmentation. Most of these processes are associated with genes that have been implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development. Bon is associated with sites on the polytene chromosomes and can interact with numerous Drosophila nuclear receptor proteins. Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of beta FTZ-F1 and behaves as a transcriptional inhibitor in vivo.
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