期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 1, 期 4, 页码 665-675出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(00)00051-5
关键词
cocaine; lymphocyte proliferation; local anaesthetic; monoamine reuptake inhibitor; HPA axis; corticosterone
资金
- NIDA NIH HHS [DA05849] Funding Source: Medline
- NIMH NIH HHS [MH11589] Funding Source: Medline
Cocaine has previously been shown to decrease mitogen-induced T lymphocyte proliferation in rats following intravenous administration. However, in this report, it is demonstrated that central administration of cocaine (1-50 mug) had no effect on lymphocyte proliferation responses. Similarly, the quaternary derivative, cocaine methiodide, also suppressed lymphocyte proliferation only when administered peripherally (6.5 mg/kg), and not centrally (1-20 mug) These results suggest that the effects of cocaine were mediated through a peripheral mechanism. Since significant elevations in plasma corticosterone were observed with all routes of administration of cocaine. the effects of cocaine did not appear to be due entirely to activation of the HPA axis. Instead, the peripheral administration of the local anesthetic, lidocaine (5 mg/kg) or the monoamine reuptake inhibitor. RTI-55 (2-5 mg/kg), produced significant suppressive effects on proliferation, suggesting that both of these peripheral activities of cocaine may be involved in the alteration of lymphocyte responses. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据