期刊
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
卷 137, 期 4, 页码 -出版社
ASME
DOI: 10.1115/1.4029430
关键词
sclera; glaucoma; collagen fiber; finite element model; digital image correlation; inverse finite element analysis; wide angle X-ray scattering
资金
- Public Health Service [EY021500, EY02120, EY01765]
- Fight For Sight [1360]
- Leonard Wagner Charitable Trust
- Saranne and Livingston Kosberg
- Fight for Sight [1359/60] Funding Source: researchfish
- Medical Research Council [MR/K000837/1] Funding Source: researchfish
- MRC [MR/K000837/1] Funding Source: UKRI
The objective of this study was to measure the collagen fiber structure and estimate the material properties of 7 human donor scleras, from age 53 to 91. The specimens were subjected to inflation testing, and the full-field displacement maps were measured by digital image correlation. After testing, the collagen fiber structure was mapped using wide-angle X-ray scattering. A specimen-specific inverse finite element method was applied to calculate the material properties of the collagen fibers and interfiber matrix by minimizing the difference between the experimental displacements and model predictions. Age effects on the fiber structure and material properties were estimated using multivariate models accounting for spatial autocorrelation. Older age was associated with a larger matrix stiffness (p = 0.001), a lower degree of fiber alignment in the peripapillary sclera (p = 0.01), and a lower mechanical anisotropy in the peripapillary sclera (p = 0.03).
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