期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 19, 页码 10501-10510出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b01984
关键词
chitosan; drug release; drug delivery; hypromellose; polyelectrolyte complex
资金
- Research Grants Council of Hong Kong [HKU 719813E, 17304514, HKU 707712P]
- National Natural Science Foundation of China [NSFC51206138/E0605]
- University of Hong Kong [201211159090, 201309160035, 201311159105, 201409176157]
Polyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2-3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.
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