期刊
INFECTION AND IMMUNITY
卷 69, 期 4, 页码 2700-2707出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.4.2700-2707.2001
关键词
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资金
- NIDCR NIH HHS [R01 DE 07233, P30 DE 09737] Funding Source: Medline
The mouth may provide an accessible model for studying bacterial interactions with human cells in vivo. Using fluorescent in situ hybridization and laser scanning confocal microscopy, we found that human buccal epithelial cells from 23 of 24 subjects were infected with intracellular bacteria, including the periodontal pathogens Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, as well as other species which have yet to be identified. Buccal cell invasion may allow fastidious anaerobes to establish themselves in aerobic sites that otherwise present an unfavorable environment. Exfoliated buccal epithelial cells might provide a protected route for bacterial transmission between different oral sites within and between hosts.
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