期刊
ATHEROSCLEROSIS
卷 155, 期 2, 页码 425-430出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0021-9150(00)00577-3
关键词
HDL particle size; hormone replacement therapy; menopause
Menopause is accompanied by changes in lipoprotein particles that include an increase in density of low density lipoproteins (LDL) and high density lipoproteins (HDL) particles. The effect of 3 months of oral hormone replacement therapy (HRT) on lipoprotein particle size in postmenopausal women who were randomized to (I)estrogen replacement therapy (ERT) alone (either 17 beta -estradiol (1 mg) or conjugated equine estrogens (CEE) (0.625 mg); (2) combination therapy (17 beta -estradiol plus medroxyprogesterone acetate (MPA) or CEE plus MPA): and (3) placebo were examined. Lipoprotein subclass concentrations and particle size were quantified by nuclear magnetic resonance spectroscopy (NMR). Combination HRT resulted in significant (P = 0.002) increases in HDL particle size as compared with those on placebo Formulations or ERT alone. Women assigned to combined HRT had lower concentrations of smaller HDL particles after 3 months (P = 0.005) and higher concentrations of larger HDL particles (P = 0.02), whereas women assigned to ERT or placebo experienced non-significant changes. in summary. combined HRT increases HDL particle size by altering concentrations of the smallest and largest HDL subspecies. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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