期刊
BIOCHEMISTRY
卷 48, 期 20, 页码 4417-4422出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi900441v
关键词
-
资金
- National Institutes of Health [GM84191]
Guanylyl cyclases (GCs) catalyze the conversion of GTP to the second messenger cGMP. While some transmembrane GCs are receptors for extracellular ligands, other transmembrane GCs such as retinal-specific GC-E and GC-F are stimulated by cellular proteins. GC-D is expressed in a special group of olfactory sensory neurons. However, the direct regulatory mechanism of GC-D activity is not completely understood. Here we have demonstrated that bicarbonate directly increases the activity of purified GC-D. Bicarbonate also increases the cGMP levels in cells expressing GC-D. These results identify bicarbonate as a small Molecule that regulates GC-D.
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