期刊
OPHTHALMOLOGY
卷 108, 期 4, 页码 711-720出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0161-6420(00)00643-6
关键词
-
资金
- NEI NIH HHS [EY-06855, EY-13132] Funding Source: Medline
Purpose: To clarify the pathogenesis of choroideremia. Study Design: Human tissue study. Tissues: Eyes of an 88-year-old symptomatic female carrier of choroideremia (CHM) and six normal, age-matched donors. Methods: The eyes were processed for histopathologic examination, including immunocytochemistry with an antibody against the CHM gene product, REP-1, and retinal cell-specific markers. Results: The CHM carrier retina showed patchy degeneration, but the photoreceptor and retinal pigment epithelium (RPE) loss appeared to be independent. The choriocapillaris was normal except where retinal areas were severely degenerate. The CHM gene product, REP-1, was localized to the cytoplasm of rods but not cones, Conclusions: It has generally been considered that photoreceptor degeneration in CHM is secondary to loss of the choriocapillaris or RPE, This study suggests that the rod photoreceptors are a primary site of disease in CHM, (C) 2001 by the American Academy of Ophthalmology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据