期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 2, 期 4, 页码 294-305出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/35067100
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Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
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