期刊
PHARMACOLOGY & THERAPEUTICS
卷 90, 期 1, 页码 35-43出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0163-7258(01)00123-1
关键词
portal hypertension; microspheres; liver flow; rat
Several portal hypertensive animal models are available and frequently used for haemodynamic studies. The portal venous inflows, measured with microspheres in pentobarbital anaesthetised rats, are compared here. The partial portal Vein ligation model is characterised by a high portal venous inflow, together with extensive portal systemic shunting, at the cost of portal sinusoidal flow. In carbon tetrachloride-induced micronodular cirrhosis, portal sinusoidal flow, which reaches liver parenchyma, is high, and this is more pronounced in the presence of ascites. In bile duct ligation and excision-induced cirrhosis, an increase in liver weight was not equally followed by an increase in portal sinusoidal flow, pointing to a relatively underperfused liver. (C) 2001 Elsevier Science Inc. All rights reserved.
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