期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 193, 期 7, 页码 785-792出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.193.7.785
关键词
bronchiolitis, viral; immunity, mucosal; immunity, cellular; pulmonary infection; eosinophil
T cells secreting interleukin (IL)-4 and IL-5 (T helper cell type 3 [Th2] cells) play a detrimental role in a variety of diseases, but specific methods of regulating their activity remain elusive, T1/ST2 is a surface ligand of the IL-1 receptor family, expressed on Th2- but not on interferon (IFN)-gamma -producing Th1 cells. Prior exposure of BALB/c mice to the attachment (G) or fusion (F) protein of respiratory syncytial virus (RSV) increases illness severity during intranasal RSV challenge, due to Th2-driven lung eosinophilia and exuberant Th1-driven pulmonary infiltration, respectively. We used these polar models of viral illness to study the recruitment of T1/ST2 cells to the lung and to test the effects of anti-T1/ST2 treatment in vivo. T1/ST2 was present on a subset of CD4(+) cells from mice with eosinophilic lung disease. Monoclonal anti-T1/ST2 treatment reduced lung inflammation and the: severity of illness in mice with Th2 (but not Th1) immunopathology. These results show that inhibition of T1/ST2 has a specific effect on virally induced Th2 responses and suggests that therapy targeted at this receptor might be of value in treating Th2-driven illness.
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