期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 115, 期 1-2, 页码 91-100出版社
ELSEVIER
DOI: 10.1016/S0165-5728(01)00270-3
关键词
glossopharyngeal nerve transection; lipopolysaccharide; interleukin-1 beta; fever; soft palate; rat
资金
- NIAAA NIH HHS [AA09850] Funding Source: Medline
Glossopharyngeal afferents may be the neural channel by which immune challenge of the posterior oral cavity conveys information to the brain, If this is the case, then bilateral transection of the glossopharyngeal nerves (GLOx) should disrupt this communication. Injection of lipopolysaccharide (LPS) or interleukin (IL)-1 beta into the soft palate (ISP) of sham-operated rats induced a dose-related febrile response. GLOx significantly attenuated the febrile response induced by ISP injection of both LPS and IL-IP. In contrast, GLOx did not affect the febrile response when LPS or IL-1 beta were injected intraperitoneally, indicating that the effect of GLOx is not systemic. These results provide experimental evidence for a novel neural pathway for immune-to-brain communication. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据