期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 115, 期 1-2, 页码 135-143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(01)00259-4
关键词
fractalkine; LPS; intracerebroventricular injection; TNF-alpha.; 8-isoprostanes
Fractalkine is a chemokine widely and constitutively expressed in the brain and, as suggested by in vitro studies, it is involved in brain inflammatory responses. In this study, we have investigated the in vivo anti-inflammatory potential of fractalkine in a model of neuroinflammation induced by intracerebroventricular injection of lipopolysaccharide (LPS) in rats. LPS induces a rapid and acute production of the pro-inflammatory cytokine, TNF alpha, in hippocampus and cerebrospinal fluid (CSF), and an increase of 8-isoprostane levels, a marker of oxidative stress, in hippocampus. Although intracerebroventricular injection of fractalkine has no effect on TNF alpha and 8-isoprostane production, neutralization of endogenous fractalkine within the brain with a specific anti-fractalkine antibody potentiates LPS effects. These data emphasize the involvement of constitutive brain fractalkine in the control of inflammatory reaction in CNS. (C) 2001 Elsevier Science B.V. All rights reserved.
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