期刊
ORGANIC LETTERS
卷 3, 期 7, 页码 1053-1056出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol015626o
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资金
- NIGMS NIH HHS [GM59157-01] Funding Source: Medline
[GRAPHICS] A formal synthesis of the muscarinic M-1 receptor antagonist (-)-TAN1251A (7) from L-tyrosine is described. Central to this venture has been the construction of the 1-azaspiro[4.5]decane skeleton present in the natural product by an N-methoxy-N-acylnitrenium ion-induced spirocyclization. The dienone generated in this transformation, 10, was converted to (-)-TAN1251A via tricycle 9, an intermediate in Kawahara's recent synthesis of racemic 7.
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