期刊
ENZYME AND MICROBIAL TECHNOLOGY
卷 28, 期 6, 页码 527-536出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0141-0229(01)00293-9
关键词
ethanolamine; fatty amide; N-acylethanolamine; emulsifier; enzymatic synthesis; lipase
The condensation of a primary amine with fatty acids has been studied to determine optimum conditions for selective formation of amide surfactants via enzymatic amidification. Monoacylated ethanolamide and the diacylated amide-ester can be isolated from the reaction mixture, but the monoacylated ester cannot be isolated. The selectivity of the reaction depends on the solubility of the intermediate amide. Continuous precipitation of this product decreases the amount of amide-ester produced. Solubility values of the desired product (amide) are reported for different conditions. In acetonitrile, the ethyl ester of the corresponding fatty acid has been used successfully to avoid formation/precipitation of the ion-pair of the precursor reagents. In this medium, use of the transacylation reaction permits one to accelerate the reaction without producing a significant change in the selectivity toward the intermediate amide. This strategy is not successful in n-hexane where the solubilities of both ethanolamine and its ion-pair with lauric acid are similar. Results obtained for high loadings of substrates have been analyzed. In n-hexane and acetonitrile, the kinetics of the direct acylation reactions are controlled by the limited solubility of the ion pair formed by the two precursor reagents For the transacylation reaction in acetonitrile, at a sustrate loading of 2 mol l(-1) selective production of as much as 92 mole percent N-acyl ethanolamine was observed in only 1.5 h. (C) 2001 Elsevier Science Inc. All rights reserved.
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