期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 7, 页码 871-874出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00098-1
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Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.
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