期刊
FEMS MICROBIOLOGY LETTERS
卷 197, 期 2, 页码 131-138出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2001.tb10594.x
关键词
GPI-anchored receptor; caveolae; raft; endocytosis; bacteria; toxin
类别
资金
- NIAID NIH HHS [AI 35678] Funding Source: Medline
- NIDDK NIH HHS [DK 50814] Funding Source: Medline
An increasing number of pathogens or their toxins appear to utilize glycosylphosphatidylinositol(GPI)-anchored receptors to trigger entry into immune and other host cells. Since these receptors have no transmembrane and intracellular moieties: how endocytosis is initiated is unclear. Recently. CD48 on mast cell membranes was shown to trigger endocytosis of bacteria via a route that avoids fusion with lysosomes and by a mechanism involving discrete cellular entities called caveolae, The localization of CD48 within caveolae appears to be a prerequisite for caveolae-mediated bacterial entry. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.
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