期刊
NEUROSCIENCE LETTERS
卷 302, 期 1, 页码 41-44出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01654-8
关键词
resveratrol; paclitaxel; apoptosis; neuroprotection; caspases; human neuroblastoma; SH-SY5Y cells
Paclitaxel, an anticancer drug, induces apoptosis in human neuroblastoma cell line SH-SY5Y. The addition of trans-resveratrol, a natural antioxidant present in grapes and red wine, to SH-SY5Y cultures exposed to paclitaxel significantly reduces cellular death. The neuroprotective action of trans-resveratrol is due neither to its antioxidant capacity nor to interference with the polymerization of tubulin induced by paclitaxel. However, trans-resveratrol is able to inhibit the activation of caspase 7 and degradation of poly-(ADP-ribose)-polymerase which occur in SH-SY5Y exposed to paclitaxel. Resveratrol, therefore, exerts its anti-apoptotic effect by modulating the signal pathways that commit these neuronal-like cells to apoptosis. (C) 2001 Published by Elsevier Science Ireland Ltd.
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