期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 30, 期 8, 页码 877-883出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(01)00474-9
关键词
astringinin; ischemia-reperfusion; antiarrhythmia; myocardial infarction; antioxidants; nitric oxide; free radicals
Oxidative stress plays an important role in the pathogenesis of myocardial ischemia and infarction. Antioxidants might then be beneficial in the prevention of these diseases. Astringinin (3,3 ' ,4 ' ,5-tetrahydroxystilbene), a resveratrol (3,4 ' ,5-trihydroxystilbene) analogue with considerably higher antioxidative activity and free radical scavenging capacity, was introduced to examine its cardioprotective effects in ischemia or ischemia-reperfusion (I/R) rats. In the present study, the left main coronary artery was occluded by the following procedures: (i) 30 min occlusion, (ii) 5 min occlusion followed by 30 min reperfusion, and (iii) 4 h occlusion. Animals were infused with and without astringinin before coronary artery occlusion. Mortality, and the severity of ischemia- and I/R-induced arrhythmias were compared. Pretreatment of astringinin dramatically reduced the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) during either ischemia or IIR period. Astringinin at 2.5 X 10(-5) and 2.5 X 10(-4) g/kg completely prevented the mortality of animals during ischemia or I/R. During the same period, astringinin pretreatment also increased nitric oxide (NO) and decreased lactate dehydrogenase (LDH) levels in the carotid blood. In animals subjected to 4 h coronary occlusion, the cardiac infarct size (expressed as a percentage of occluded zone) was reduced from 44.4 +/- 4.1% to 19.1 +/- 2.4% by astringinin (2.5 x 10(-4) g/kg), We conclude that, astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart. The beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production. (C) 2001 Elsevier Science Inc.
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