期刊
GENES & DEVELOPMENT
卷 15, 期 8, 页码 1021-1030出版社
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.869101
关键词
spermatogenesis; TAF; TFIID; Drosophila; cannonball; dTAF(II)80
资金
- NICHD NIH HHS [HD082778] Funding Source: Medline
Alternate forms of the general transcription machinery have been described in several tissues or cell types. However, the role of tissue-specific TBP-associated factors (TAF(II)s) and other tissue-specific transcription components in regulating differential gene expression during development was not clear. Here we show that the cannonball gene of Drosophila encodes a cell type-specific homolog of a more ubiquitously expressed component of the general transcription factor TFIID. cannonball is required in vivo for high level transcription of a set of stage- and tissue-specific target genes during male gametogenesis. Regulation of transcription by cannonball is absolutely required for spermatogenesis, as null mutations block meiotic cell cycle progression and result in a complete failure of spermatid differentiation. Our results demonstrate that cell type-specific TAF(II)s play an important role in developmental regulation of gene expression.
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