期刊
JOURNAL OF NEUROSCIENCE
卷 21, 期 8, 页码 2678-2686出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.21-08-02678.2001
关键词
DEG/ENaC channels; mechanosensory; mechanotransduction; touch; nociception; dorsal root ganglion; unidirectional transport; degenerin
资金
- NINDS NIH HHS [NS38253-01, R01 NS038253] Funding Source: Medline
Mammalian brain sodium channel (BNaC, also known as BNC/ ASlC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the BNaC1 alpha isoform is expressed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception) and few small nociceptor neurons (which include high-threshold mechanoreceptors). BNaC1 alpha is transported from DRG cell bodies to sensory terminals in the periphery, but not to the spinal cord, and is located specifically at specialized cutaneous mechanosensory terminals, including Meissner, Merkel, penicillate, reticular, lanceolate, and hair follicle palisades as well as some intraepidermal and free myelinated nerve endings. Accordingly, BNaC1 alpha channels might participate in the transduction of touch and painful mechanical stimuli.
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