期刊
BRAIN RESEARCH
卷 898, 期 2, 页码 350-357出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(01)02018-2
关键词
activated caspase-3; neurofibrillary tangle; senile plaque; neuropathology; Alzheimer's disease; cell death
Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据