期刊
NEUROSCIENCE LETTERS
卷 302, 期 2-3, 页码 117-120出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01688-3
关键词
GSK-3 beta; beta-catenin; dishevelled; Wnt signalling; schizophrenia; frontal cortex
Cytoarchitectural abnormalities have been reported in the cortex in schizophrenia. These suggest a developmental origin for this disorder. The Wnt signalling pathway is involved in the regulation of brain development; disruption of this pathway may lead to abnormal cortical development. In this study levels of three components of the Wnt signalling pathway; glycogen synthase kinase-3 beta (GSK-3 beta), beta -catenin and dishevelled-2 (Dvl-2) were determined in the prefrontal cortex of ten schizophrenic and ten control individuals using immunoblotting. GSK-3 beta levels were significantly reduced in the schizophrenic group, while levels of beta -catenin and Dvl-2 did not differ between groups. This provides further evidence for an abnormality of the Wnt signalling pathway in schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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