期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 8, 页码 1089-1092出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00141-X
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A lipophilicity constrained library of 5-carboxamido 1-benzyl-3-(3-dimethylaminoproploxy)-1H-pyrazoles was prepared by solution-phase parallel synthesis with removal of acidic by-products using the strongly basic MP-carbonate resin. Compounds show both activation of soluble guanylate cyclase and inhibition of platelet aggregation. Compound 12 also shows 22% oral bioavailability in rats. (C) 2001 Elsevier Science Ltd. All rights reserved.
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