期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1538, 期 2-3, 页码 283-289出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4889(01)00079-9
关键词
hyaluronan; migration; proliferation; adhesion
Expression of the hyaluronan synthase gene in hyaluronan-deficient CI-IO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form. Hyaluronan producing CHO cells showed reduced initial cell adhesion, migration, proliferation and density at contact inhibition, but no difference in random migration determined by the Boyden chamber assay. Addition of hyaluronan to the medium of CHO cells reduced migration, proliferation and initial cell adhesion. In contrast, coating the plastic dish with hyaluronan enhanced initial cell adhesion. These results are discussed in the contest of the perplexing properties of hyaluronan on cellular functions. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据