期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 1219-1223出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140093
关键词
acute kidney injury; cell cycle; microRNA (miRNA); p53
资金
- Kidney Research UK [RP24/2009, PDF6/2013]
- Kidney Research UK [PDF6/2013, RP24/2009] Funding Source: researchfish
miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) in the context of kidney transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G(2)/M cell cycle arrest of PTCs and AKI. Recent findings from our laboratory and others presented in this review implicate miRNA regulation of the cell cycle in the pathology of AKI.
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