期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 1756-1761出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140201
关键词
chemical genetics; enolase; glyceraldehyde-3-phosphate dehydrogenase (GAPDH); glycolysis; moonlighting; small molecule
资金
- National Research Foundation of Korea (MEST basic science research programme) [NRF-2012R1A1B4003460, NRF-2012R1A1B5000462]
- Ministry of Health & Welfare, Republic of Korea [HI12C0275]
- BioImaging Research Center, Gwangju Institute of Science and Technology
Glycolysis is an ancient biochemical pathway that breaks down glucose into pyruvate to produce ATP. The structural and catalytic properties of glycolytic enzymes are well-characterized. However, there is growing appreciation that these enzymes participate in numerous moonlighting functions that are unrelated to glycolysis. Recently, chemical genetics has been used to discover novel moonlighting functions in glycolytic enzymes. In the present mini-review, we introduce chemical genetics and discuss how it can be applied to the discovery of protein moonlighting. Specifically, we describe the application of chemical genetics to uncover moonlighting in two glycolytic enzymes, enolase and glyceraldehyde dehydrogenase. This led to the discovery of moonlighting roles in glucose homoeostasis, cancer progression and diabetes-related complications. Finally, we also provide a brief overview of the latest progress in unravelling the myriad moonlighting roles for these enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据