期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 184-187出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20130211
关键词
exonuclease; gene expression; mRNA; mRNA decay; poly(A) tail
资金
- European Research Council (ERC) [261151]
- Medical Research Council [U105192715]
- European Research Council (ERC) [261151] Funding Source: European Research Council (ERC)
- MRC [MC_U105192715] Funding Source: UKRI
- Medical Research Council [MC_U105192715] Funding Source: researchfish
Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'-> 5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2-Pan3 deadenylation complex.
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