期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 742-746出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140057
关键词
cancer; GTPase; HRAS; KRAS; NRAS
资金
- North West Cancer Research
- Wellcome Trust
RAS proteins are key signalling hubs that are oncogenically mutated in 30 % of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.
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