期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 1256-1260出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140086
关键词
mRNA localization; P-body; Socchoromyces cerevisioe; stress granule
资金
- Wellcome Trust [099732/Z/12/Z]
- Wellcome Trust [099732/Z/12/Z] Funding Source: Wellcome Trust
The localization of mRNA forms a key facet of the post-transcriptional control of gene expression and recent evidence suggests that it may be considerably more widespread than previously anticipated. For example, defined mRNA-containing granules can be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces cerevisiae, examining connections between organellar mRNA localization and the response to stress. We also review recent data suggesting that even where there is a global relocalization of mRNA, the specificity and kinetics of this process can be regulated.
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