4.4 Article

Current perspectives on RNA secndary structure probing

期刊

BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 1251-1255

出版社

PORTLAND PRESS LTD
DOI: 10.1042/BST20140084

关键词

nucleotide; RNA structure; selective 2 ' hydroxy acylation analysed by primer extension (SHAPE); structural analysis

资金

  1. Medical Research Council [G0800142]
  2. Wellcome Trust [078007/Z/05/Z]
  3. Biomedical Research Centre
  4. Wellcome Trust [078007/Z/05/Z] Funding Source: Wellcome Trust
  5. MRC [G0800142, G0801709] Funding Source: UKRI
  6. Medical Research Council [G0801709, G0800142] Funding Source: researchfish

向作者/读者索取更多资源

The range of roles played by structured RNAs in biological systems is vast. At the same time as we are learning more about the importance of RNA structure, recent advances in reagents, methods and technology mean that RNA secondary structural probing has become faster and more accurate. As a result, the capabilities of laboratories that already perform this type of structural analysis have increased greatly, and it has also become more widely accessible. The present review summarizes established and recently developed techniques. The information we can derive from secondary structural analysis is assessed, together with the areas in which we are likely to see exciting developments in the near future.

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