期刊
ONCOGENE
卷 20, 期 19, 页码 2401-2412出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204389
关键词
AP-1; Fos proteins; Jun proteins; development; bone biology; tumorigenesis
Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1, Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles olf AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis.
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