期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 41, 期 -, 页码 1159-1165出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20130135
关键词
cell communication; lipid bilayer; membrane protein pore; protocell; prototissue; synthetic biology
资金
- Clarendon Scholarship
- EU Commission in the form of a Marie Curie Intra-European fellowship
Realization of a functional artificial cell, the so-called protocell, is a major challenge posed by synthetic biology. A subsequent goal is to use the protocellular units for the bottom-up assembly of prototissues. There is, however, a looming chasm in our knowledge between protocells and prototissues. In the present paper, we give a brief overview of the work on protocells to date, followed by a discussion on the rational design of key structural elements specific to linking two protocellular bilayers. We propose that designing synthetic parts capable of simultaneous insertion into two bilayers may be crucial in the hierarchical assembly of protocells into a functional prototissue.
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