期刊
BIOMATERIALS
卷 22, 期 9, 页码 923-928出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(00)00256-8
关键词
mucoadhesive; template polymerization; poly(acrylic acid); chitosan; adhesive force; dissolution degree
A novel mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of chitosan for transmucosal drug delivery system (TMD). FT-IR results indicated that polymer complex was formed between poly(acrylic acid) (PAA) and chitosan through hydrogen bonding. Glass transition temperature (T-g) of chitosan and PAA in the PAA/chitosan polymer complexes was inner-shifted compared with T-g of chitosan and PAA itself. This may be due to the increased miscibility of PAA with chitosan through the hydrogen bonding. The crystallinity of chitosan in the PAA/chitosan polymer complexes was decreased with polymer complex formation with PAA. The dissolution rate of the PAA/chitosan polymer complex was dependent on pH and ratio of PAA/chitosan. The mucoadhesive force of PAA/chitosan polymer complex was similar to a commericial product, Carbopol 971P NF. (C) 2001 Published by Elsevier Science Ltd.
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