期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 114, 期 2, 页码 143-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0166-6851(01)00245-6
关键词
Trypanosoma cruzi; mucins; sialic acid; trans-sialidase; GPI; glycosylation
资金
- NIAID NIH HHS [AI21334] Funding Source: Medline
Trypanosoma cruzi expresses at its surface large amounts of mucin-like glycoproteins. The T. cruzi mucins (TcMUC), a group of highly glycosylated GPI-anchored proteins rich in Thr, Ser, and Pro residues, are expressed in high copy numbers in both insect and mammalian stages of the parasite. These molecules are encoded by a multigene family and contain a unique type of glycosylation consisting of several sialylated O-glycans linked to the protein backbone via Nw-acetylglucosamine residues. The TcMUC are important because of their role in host cell invasion and the ability to induce secretion of proinflammatory cytokines and nitric oxide in activated macrophages. The TcMUC are also significant in being the major substrate For the cell surface trans-sialidase. In this review, we summarize the recent knowledge on the molecular structure and function of this family of T. cruzi glycoproteins. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据