期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 41, 期 -, 页码 273-276出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120248
关键词
angiogenesis; cancer; coagulation; exosome; hypoxia; microvesicle
资金
- Swedish Cancer Fund
- Swedish Research Council
- Swedish Society of Medicine
- Physiographic Society, Lund
- Gunnar Nilsson Foundation
- Kamprad Foundation
- Lund University Hospital
- Governmental funding of clinical research within the national health services (ALF)
Over the last few decades, extensive studies by several groups have introduced the concept of cell-derived secreted extracellular membrane vesicles as carriers of complex molecular information. Owing to their pleiotropic biological effects and involvement in a wide variety of biological processes, extracellular membrane vesicles have been implicated in physiological as well as pathological events, including tumour development and metastasis. In the present review, we discuss the role of secreted membrane vesicles in intercellular communication with a focus on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis.
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