期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 40, 期 -, 页码 573-579出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120062
关键词
cytochrome P450; drug discovery; fragment-based drug discovery; high-throughput screening (HTS); Mycobacterium tuberculosis; tuberculosis
资金
- Cambridge Commonwealth Trust, University of Cambridge
- Cambridge Overseas Trust, University of Cambridge
- Christ's College, University of Cambridge
- Biotechnology and Biological Sciences Research Council [BB/I019227/1, BB/I019669/1] Funding Source: researchfish
- BBSRC [BB/I019669/1, BB/I019227/1] Funding Source: UKRI
TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action. In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns that are being used to probe their potential druggability.
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