期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 40, 期 -, 页码 26-30出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20110623
关键词
cancer; growth factor; microRNA (miRNA); network; tyrosine kinase
资金
- National Cancer Institute [CA72981]
- M.D. Moross Institute for Cancer Research
- Kekst Family Institute for Medical Genetics
- Women's Health Research Center
- Bennett-Pritzker Endowment Fund
- Marvelle Koffler Program for Breast Cancer Research
- Harry and Jeanette Weinberg Women's Health Research Endowment
- European Commission
- German Research Foundation
Stringent regulation of biochemical signalling pathways involves feedback and feedforward loops, which underlie robust cellular responses to external stimuli. Regulation occurs in all horizontal layers of signalling networks, primarily by proteins that mediate internalization of receptor-ligand complexes, dephosphorylation of kinases and their substrates, as well as transcriptional repression. Recent studies have unveiled the role of miRNAs (microRNAs), post-transcriptional regulators that control mRNA stability, as key modulators of signal propagation. By acting as genetic switches or fine-tuners, miRNAs can directly and multiply regulate cellular outcomes in response to diverse extracellular signals. Conversely, signalling networks temporally control stability, biogenesis and abundance of miRNAs, by regulating layers of the miRNA biogenesis pathway. In the present mini-review, we use a set of examples to illustrate the extensive interdependence between miRNAs and signalling networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据