期刊
BRITISH JOURNAL OF NUTRITION
卷 85, 期 5, 页码 517-547出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1079/BJN2000280
关键词
selenium; cardiomyopathy; cancer; food systems; chemoprevention
Food systems need to produce enough of the essential trace element Se to provide regular adult intakes of at least 40 mug/d to support the maximal expression of the Se enzymes, and perhaps as much as 300 mug/d to reduce risks of cancer. Deprivation of Se is associated with impairments in antioxidant protection, redox regulation and energy production as consequences of suboptimal expression of one or more of the Se-containing enzymes. These impairments may not cause deficiency signs in the classical sense, but instead contribute to health problems caused by physiological and environmental oxidative stresses and infections. At the same time, supranutritional intakes of Se, i.e. intakes greater than those required for selenocysteine enzyme expression, appear to reduce cancer risk. The lower, nutritional, level is greater than the typical intakes of many people in several parts of the world, and few populations have intakes approaching the latter, supranutritional, level. Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.
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