期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 40, 期 -, 页码 789-793出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120053
关键词
heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1); KH-type splicing regulatory protein (KSRP); Lin28; MCP-induced protein 1 (MCPIP1); microRNA terminal loop; RNA-binding protein
资金
- Medical Research Council [G1000564]
- Wellcome Trust Centre [077707, 092076]
- MRC [G1000564] Funding Source: UKRI
- Medical Research Council [G1000564] Funding Source: researchfish
Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.
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