期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 1705-1709出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20110603
关键词
Coenorhabditis elegons; chromatin; DNA adenine methyltransferase identification (DamID); heterochromatin; lamina; nuclear envelope
资金
- Israel Science Foundation
- U.S.A.-Israel Binational Science Foundation (BSF)
- Ministry of Health (MOH)
In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of specific gene retention at the nuclear periphery and release to the nuclear interior upon gene activation. We also discuss recent data showing that mutations in lamin proteins affect gene positioning and expression, providing a potential mechanism for how these mutations lead to tissue-specific diseases.
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