期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 1161-1165出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0391161
关键词
cytoskeletal motor; motility; mRNA localization; mRNA-protein complex assembly (mRNP assembly); RNA recognition
资金
- Medical Research Council
- Lister Institute
- MRC [MC_U105178790] Funding Source: UKRI
- Medical Research Council [MC_U105178790] Funding Source: researchfish
It has become increasingly apparent in recent years that the subcellular localization of specific mRNAs is a prevalent method for spatially controlling gene expression. In most cases, targeting of mRNAs is mediated by transport along cytoskeletal filaments by molecular motors. However, the means by which specific messages are recognized and linked to the motors are poorly understood. Here, I will provide an overview of recent progress in elucidating the molecular mechanisms and principles of mRNA transport, including several studies highlighting the co-operation of different motors during the localization process. Important outstanding questions will also be highlighted.
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