期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 1240-1246出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0391240
关键词
cyclo-oxygenase (COX); cytochrome P450 (CYP450); eicosanoid; lipoxygenase (LOX); mass spectrometry; polyunsaturated fatty acid (PUFA)
资金
- YCR (Yorkshire Cancer Research)
- WoW (Wellbeing of Women)
Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators.
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