期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 1725-1728出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20110668
关键词
alpha-catenin; chromatin; laminopathy; linker of nucleoskeleton and cytoskeleton complex (LINC complex); nesprin; Wnt signalling; wound healing
资金
- Center for Molecular Medicine Cologne (CMMC) Medical Faculty
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Nesprins (nuclear envelope spectrin repeat proteins), also known as SYNE (synaptic nuclear envelope protein), MYNE (myocyte nuclear envelope protein), ENAPTIN and NUANCE, are proteins that are primarily components of the nuclear envelope. The nuclear envelope is a continuous membrane system composed of two lipid bilayers: an inner and an outer nuclear membrane. Nesprins are components of both nuclear membranes and reach into the nucleoplasm and the cytoplasm, where they undergo different interactions and have the potential to influence transcriptional processes and cytoskeletal activities.
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