期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 39, 期 -, 页码 961-965出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0390961
关键词
bactericidal/permeability-increasing protein (BPI); BPI fold-containing (BPIF); lipopolysaccharide-binding protein (LBP); palate, lung and nasal epithelium clone (PLUNC)
资金
- Wellcome Trust [107726]
- British Lung Foundation
- Sheffield Hospitals Charitable Trust
PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of sequence similarity coupled with multiple examples of species-specific gene acquisition and gene loss. Vertebrate genomes contain multiple examples of genes that do not meet our original definition of what is required to be a member of the PLUNC family, namely conservation of exon numbers/sizes, overall protein size, genomic location and the presence of a conserved disulfide bond. This suggests that evolutionary forces have continued to act on the structure of this conserved domain in what are likely to be functionally important ways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据