期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1581-1586出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381581
关键词
eukaryotic initiation factor (eIF); internal ribosome entry site (IRES); IRIS trans acting factor (ITAF); translation initiation; untranslated region (UTR)
资金
- Biotechnology and Biological Sciences Research Council
- BBSRC [BB/F000065/1] Funding Source: UKRI
- MRC [MC_UP_A600_1023] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F000065/1] Funding Source: researchfish
- Medical Research Council [MC_UP_A600_1023] Funding Source: researchfish
the majority of mRNAs in eukaryotic cells are translated via a method that is dependent upon the recognition of and binding to the methylguanosine cap at the 5 end of the mRNA by a set of protein factors termed eIFs (eukaryotic initiation factors) However many of the eIFs involved in this process are modified and become less active under a number of pathophysiological stress conditions including amino acid starvation heat shock hypoxia and apoptosis During these conditions the continued synthesis of proteins essential to recovery from stress or maintenance of a cellular programme is mediated via an alternative form of translation initiation termed IRES (internal ribosome entry site) mediated translation This relies on the mRNA containing a complex as acting structural element in its 5 UTR (untranslated region) that is able to recruit the ribosome independently of the cap and is often dependent upon additional factors termed ITAFs (IRES irons acting factors) A limited number of ITAFs have been identified to date particularly for cellular IRESs and it is not yet fully understood how they exert their control and which cellular pathways are involved in their regulation
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据