期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1077-1081出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381077
关键词
alternative polyadenylation; antisense RNA; chromatin; flowering time control; spen
资金
- British Biotechnology and Biological Sciences Research Council [BB/H002286/1, BB/D000653/1]
- Scottish Government (Rural and Environment Research and Analysis Directorate)
- Biotechnology and Biological Sciences Research Council [BB/D000653/1, BB/H002286/1] Funding Source: researchfish
- BBSRC [BB/D000653/1, BB/H002286/1] Funding Source: UKRI
Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thallium, components of the autonomous flowering pathway, FCA and FPA, function as genetically independent frons-acting regulators of alternative cleavage and polyadenylation. FCA and FPA directly associate with chromatin at the locus encoding the floral repressor FLC, but appear to control FLC transcription by mediating alternative polyadenylation of embedded non-coding antisense RNAs. These findings prompt the re-examination of how other factors control FLC expression, as it is formally possible that they function primarily to control alternative processing of antisense RNAs. As co-expressed sense and antisense gene pairs are wide spread in eukaryotes, alternative processing of antisense RNAs may represent a significant form of gene regulation.
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